My son has had to change his medication to deal with his manic moods.  He is taking ability and pristq wherein before he was taking depakote which made him really sick.  He has his ups and downs when he gets really depressed.  The good thing is that he comes and tells me when his on the verge of suicidal thoughts which we talk through theraputic techniques his counselor taught us to do.  It has helped in dealing with his mood swings.  I sometimes do feel scared to get up one morning and find him hanging.  I have to overcome that fear to move on.