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Misoprostol Therapy

Anonymous Author (March 2007)

I had recently a miscarriage that was quite a shock:

In the 10th week of pregnancy, my husband and I went to the obstetrician for the first ultrasound where we discovered that the baby had died in the seventh week.

Before the diagnosis, nothing indicated a miscarriage

as I had no bleeding or any other symptoms. So it was quite a surprise as I had not read anywhere that the dead foetus could remain inside my own body, a so called ‘missed miscarriage’.  

The obstetrician gave me three options:

1. to wait until the dead foetus gets transferred out by itself,

2. misoprostol therapy, or

3. to have an operation to vacuum out the dead foetus (Dilatation and curettage or D&C)

I decided to go for the second option as the third one sounded (at that early stage) too horrible and the first one was not really an option for me (apparently you can be in your 5th month of pregnancy with the dead foetus still remaining inside).  

I went on the same day to the hospital (emergency service) for misoprostal therapy. Misoprostol is a type of prostaglandin hormone. The hormone induces contractions that open the cervix (neck of the uterus / womb) to create a period / miscarriage. The nurse inserts four small hormone pills into the vagina close to the cervix. You have to lie down for one hour, so that the pills cannot move. Then you go home and wait.

The treatment should work after 24 - 48 hours and may be quite painful. However, the nurse gives you plenty of strong pain killers.

If the miscarriage has not worked after 2 days, you go back in the hospital for the same treatment. Then you wait one week.

Based on some internet research I did, the treatment should work for around 70% of cases after the first treatment and this increases to 80% probability after the second treatment. Unfortunately, I had no serious period even after the second treatment.

I decided then to go ahead with the D&C operation which was after all not as horrible as it sounds. It is a day-surgery at the hospital where the dead foetus gets removed under full anaesthesia. The procedure is fast and I had no pain after the surgery but quite some bleeding for a while.  Everybody in the hospital was very nice as they feel sorry for your loss. Even a priest came to talk to us.

My recommendation:

Decide for the misoprostol therapy if you prefer a more “natural” way of ending the miscarriage. I wanted to feel via a period that I will now lose the baby. It helped me to better understand and digest what happened. However, be aware that the treatment could be a slow process, particularly if the first dosage has not worked fully. Regarding the pain level, I cannot give a judgement as the treatment did not work with me and I had no pain at all.

Decide for the operation (D&C) if you prefer a fast, painless process of miscarriage and if you don't mind to have surgery. It is a one day procedure and the physical process of the miscarriage is over. However, the psychological process of getting over the pregnancy loss will also need some time, independent of the treatment you have chosen.

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JustineM
May 2008 | JustineM
Re: Misoprostol Therapy

I miscarriaged at 13 weeks of pregnancy but the babie only grew up till 8 weeks of pregnancy. Its heart had stopped beating. If i had carried it for longer then it would have been a still birth the doctors said. Then it was taken via curet. It happened so quickly that i never even had a chance to get my head around it. It was like the doctors where telling me a huge lie. It hurt like hell. Here i was going for my first ultra sound and waiting to see my baby but it never happened. They did an internal ultra sound to confirm this.



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emmie
May 2008 | emmie
Re: Misoprostol Therapy

Great article thanks for sharing

Emz xx



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natscan
March 2008 | natscan
Re: Misoprostol Therapy

THERE IS A TOO MUCH INFORMATION GRAPHIC WARNING ON THIS REPLY But I want to be open and honest about my experience and give people the opportunity to have information Ididn't

I am currently taking it to bring on expulsion of a missed miscarriage - which has been dead inside me for 3 weeks. I had four tablets inserted today at 1:30 at the hospital. (they must have been designed by a man because they have corners - OUCH! hexagons!??? I ask you! - Why oh Why?) (technically 9 weeks 1 day pregnant and very very sad about this whole situation)

I took pain killers at 3pm because I felt some cramping coming on. at 4:30 my legs got weak and I became cold, clammy, sweaty, nauseous and dizzy. hubby said I looked like I was strung out on drugs. I felt like I was on BAD ecstasy.

I felt like my bowels wanted to move but they wouldn't. I felt like I wanted to vomit but I couldn't.

I sat on the loo for an hour with a bucket in front of me and rocked (it helps) with a hot water bottle. The pain was the WORST I've ever felt (and I've been bitten by a red back spider - previously #1 on the most painful list, followed by a natural miscarriage - but that was ten years ago so I may have forgotten how bad that ACTUALLY was).

I noticed that breathing like I was in labour and sucking on ice cubes helped a whole lot.

at 5:30 I fell asleep for 10 minutes (on the loo) and when I woke I felt fine. Cramps gone. Ten minutes before I'm allowed to take more codeine, the pain comes back but I'm strict with myself. at 11pm I started bleeding (big time!) right on schedule.

The pain is not so bad and I'm glad I'm at home and I didn't choose something invasive that could damage my uterus or have something as dangerous as a general anaesthetic. I was terrified of this because the idea of being completely out of control in a room with strangers makes me want to run and hide.

UPDATE: 5 hours since bleeding started, haven't had another pain reliever and haven't needed one although I might in a bit. I can't sleep, not sure I want to, I just want to monitor. Cramps gone and put hot water bottle away (maybe just for now but we'll see). Still lots of blood...I have never seen so much!

I DEFINITELY think I made the right choice now.



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      HarrisonsMommy
March 2008 | HarrisonsMommy
Re: Misoprostol Therapy

Wow, how strong of you to share this.  Thank you for sharing and I hope the best for you.

Angela



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           natscan
5.00 (Excellent) | March 2008 | natscan
Re: Misoprostol Therapy

Thought i'd give you all an update.

I went this morning for a check up and i have passed it all. 

some tablets, one hour of excruciating pain and then period like symptoms seems like a very easy and humane way to do this.  My philosopy is to avoid invasive surgery at all cost so if i have another missed miscarriage i'll definitely do this again.  (fingers crossed i don't)

for the past 3 weeks while having tests and confirmation of diagnoses I have been one stressed out human.  My husband and mother have both been yelled at and i have been hysterical with tears.

since i took the drugs and passed the embryo i feel so, so much better.  Perhaps my grieving has already been done.  I'm unsure.



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whome
February 2008 | whome
Re: Misoprostol Therapy

I cant see problem here i think its brill article



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rachelcook
5.00 (Excellent) | March 2007 | rachelcook
Misoprostol Therapy
It's amazing reading this article just now, that I learnt this term, as I had never heard of it before when I went into the hospital to have the exact procedure done! Thank you so much fr sharing, this has really empowered me. We lost our little girl Jasmine at 16 weeks (14 weeks gestation). I also had a previous miscarriage at 8 weeks (6 weeks gestation) which I was only given two options (naturally or D&C), I did the D&C. I also had a miscarriage that was like a normal period, in between these two at the 4 weeks mark. I would have to say Misoprostol Therapy was a thousand times better (meaning for me ZERO pain). I started to miscarry the night before the D&C and still had to have the D&C. The pain was excruciating with the natural passing, then having to go to hospital that morning was very challenging, as well as physical recovery afterwards. The last miscarriage was more about the mental affects as I had already passed the three month mark.

The most amazing thing was that I have found out why I have been miscarrying...I don't metabolize folic acid that comes standard in a bottle from the pharmacy/chemist. I am now taking the specially made Metagenics brand called "Vessel Care" for women with my metabolizing issue.

I really suggest anyone reading this to consider that out of 100% of women, only 70% of women can metabolize the standard bottled form, 30% can't metabolize it and don't know it...well, I am 10% of the 30% that not only can't metabolize from standard tablets, I can't metabolize from food as well, which is a real issue not only for normal body functions, but most importantly for healthy conceiving. So I will now need to also take "vessel care" for life as folic acid is an essential mineral that helps my body function as well as a vital mineral during my baby making years. Clay will also need to take folic acid when we are trying. I have two genetic strands of this issue and Clay has one, so to boost our chances of a baby and a very healthy baby, we both will take folic acid when we start trying.

It is a simple blood test to find out. Also, I was taking very high levels of folic acid with my only son against advice I was given, and didn't make the connection when I decided for number 2 to follow the advice. I am so glad I did take the high doses to have a healthy boy, with only a lazy eye to speak of.

Lets hope it works for number 2


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      pumpkin
5.00 (Excellent) | April 2007 | pumpkin
Folate - wow, so much to learn!

Thank you Rachel! I am so sorry for your loss of little Jasmine!

I am going to my Ob tomorrow for the post op follow up. I will be sure to ask for the blood test re: folate. Who told you, a Doctor or Naturopath?

Fingers and toes crossed that we are both glowing by Christmas!

Thank you once again for providing this forum! It has really helped being able to communicate with people that understand 24/7! Warmest regards ;0)



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           rachelcook
5.00 (Excellent) | April 2007 | rachelcook
Folate - wow, so much to learn!
Hi, it was my Natropath, she specializes in Natural Fertility Management and worked previously in Sydney at the Jocelyn Centre (very well known)...I hope my story helps :)


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      diam
October 2nd | diam
Re: Folic acid metabolism

Hi Rachel, I have just come across this site in my search for a metabolized form of folic acid since i also have the MTHFR genetic mutation. I live in Sydney, Australia and i have been desperately trying to find a metabolized form of folic acid. You mentioned you were taking vessel care by metagenics, i would like to know where did you get it from, since it doesn't seem to be available in Australia. Were you living in Australia when you started on vessel care or not?. You also mentioned that you know a naturalpath that worked for the jocelyn centre, is she working in Australia since i would like to know what they pescribe if vessel care is not available here. I am looking foward to your reply. Thankyou so much.



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HarrisonsMommy
5.00 (Excellent) | March 2007 | HarrisonsMommy
Thank You

Thank you for sharing such an emotional thing.  I am sure it was hard to write. 

All the best to you and your family.



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pumpkin
5.00 (Excellent) | March 2007 | pumpkin
Thank you

I too had a D&C and feel that it was the best option for me. I have a cervical suture to strengthen my cervix due to cervical cancer and I had no choice but to have the D&C under a general anaesthetic, as our Ob wasn't sure that his instruments would fit and the suture would have been removed if this was the case. When I awoke the nurse promptly told me that it wasn't necessary and I cried - thank goodness! I really didn't want to go under and have the suture put back in before being allowed to fall pregnant again.

Thank you for sharing your story. In my mind I understand that miscarriage happens all too often, but in my heart, a week later, the emotion is really starting to flow and usually when I least expect it. It feels so difficult to grieve for someone that you didn't know, but hold so dear in your heart. Time is a magical thing and  I have a wonderful support network. So one day at a time ;0)



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emmysmum
5.00 (Excellent) | March 2007 | emmysmum
Hi there...
Thankyou for sharing with us your experience. I am sorry about the loss of your unborn child and i hope that you soon begin to recover from this traumatic experience soon.
We are here to support you every step of the way...
hugs
kayla.


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nell18-3
5.00 (Excellent) | March 2007 | nell18-3
Hugs
I had a baby die they spotted it at 20 weeks and it had been dead for about 6 weeks they wanted me to go for option 1!!!!! How ridiculous and cruel and barbaric. I was told it would break up and I would lose the baby bit by bit.
I have never heard of option 2
Instead I had the D & C not nice but at least it was over and could start grieving
xxx



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blackwidowkate
5.00 (Excellent) | March 2007 | blackwidowkate
hugs
Hi
hugs
Luv Deb


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